Wednesday, August 29, 2007

Buff Mice

Se-Jin Lee from Johns Hopkins has made mice more muscular. (How's that for alliteration?)

It had been previously shown that mice engineered not to make myostatin are more muscular than normal mice. Mice that make extra follistatin also have big muscles. Dr. Lee generated double mutants, mice that make no mysotatin and extra follistatin. To his surprise, the effect was additive and the mice were even more muscular.

Understanding the molecular pathways that control muscle growth could lead to new treatments for muscular dystrophy. In fact, Dr. Lee's research was funded in part by the Muscular Dystrophy Association, Jerry Lewis's favorite charity. Good timing, Dr. Lee, since the telethon is this weekend!

You can read the original paper here.